Background on Hyperimmune Egg
Polyvalent “hyperimmune" or "immune" eggs are laid by hens that have been stimulated multiple times with whole or parts of inactivated bacteria. (http://www.HyperimmuneEgg.org).
Stimulating the hens results in eggs that contain immunoglobulins (antibodies) of many classes, with the dominant class being the unique avian IgY class (1).
Even after ingestion, a large portion of these immunoglobulins are still able to bind antigen (2). Along with the production of immunoglobulins, stimulation of the hens results in generation of molecules that appear to have pro-, and anti-inflammatory, properties (3,4). Such factors appear to help the body initiate defenses against pathogens, mutating cells, and maintain immune homeostasis, by up- or down-regulating immunological responses, especially those of a defensive, autoimmune, or inflammatory nature.
[During inflammatory responses, different categories of effector immune cells communicate with one another via biological mediators (e.g., cytokines, ecosanoids) to up- (pro-inflammatory) or down-regulate (anti-inflammatory) inflammatory processes (5).]
Such inflammatory processes appear to the hallmarks of many acute and chronic conditions (6) ranging from atherosclerosis (7-9), cancer (10-12), diabetes (8-10) and obesity (9, 13-15).
Polyvalent hyperimmune egg appears to have immunoregulatory properties that help the body modulate autoimmune (16), joint (16, 17), cardiovascular (18), and gastrointestinal (19,20) function. Hyperimmune egg appears to help the body “balance” immunologic responses, up-modulating or down-modulating as necessary to enhance immunological defenses or healing.
This all-natural ingredient has over 100 patents and patent submissions including two separate patents that claim polyvalent and inhibition of RNA transcription of pro-inflammatory (3,4).
In clinical trials of HIV/AIDS (21, unpublished) subjects experienced dramatic changes in appetite, strength, feeling of well-being, digestive function, joint and muscle comfort. Also of note are the dramatic differences seen in athletic performance, endurance, recovery and strength in individuals on hyperimmune egg (22-25). [These results may be due to down-regulation of proinflammatory cytokines, which have been shown to result in fatigue (26)].
1. Carlander D. Avian IgY antibody: In vitro and in vivo Doctoral Thesis Uppsala Univ 2002 53pp. http://publications.uu.se/abstract.xsql?dbid=1710
2. Hammarström L et al. Systemic and topical immunoglobulin treatment in immunocompromised patients Immunol Rev 1994 139:43
3. US Patent # 6,420,337 Highly purified cytokine activating factor and methods of use; US Patent #7,083,809 Purified cytokine inhibitory factor
4. US Patent #7,083,809 Purified cytokine inhibitory factor
5. Luster AD. 1998 N Engl J Med 338:436
6. Ferencík M et al. Inflammation--a lifelong companion. Attempt at a non-analytical holistic view. 2007 Folia Microbiol (Praha) 52:159
7. Ziegler D. Type 2 Diabetes as an inflammatory cardiovascular disorder Cur Mol Med 2005 5:309
8. Vela D et al. The role of periadventitial fat in atherosclerosis Arch Pathol Lab Med. 2007 131:481
9. Calabro P Yeh ET. Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ Subcell Biochem 2007 42:63
10. Rakoff-Nahoum S Why cancer and inflammation? Yale J Biol Med. 2006 79:123
11. Müller-Hübenthal B, et al. Tumour Biology: tumour-associated inflammation versus antitumor immunity Anticancer Res. 2009 29:4795
12. Schetter AJ Heegaard NH Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways Carcinogenesis 2010 31:37
13. Shoelson SE et al. Obesity, inflammation, and insulin resistance Gastroenterology. 2007 132:2169
14. Wellen KE Hotamisligil GS. Inflammation, Stress, and Diabetes J Clin Invest 2005 115:1111
15. Shoelson SE, et al. Obesity, inflammation, and insulin resistance Gastroenterology 2007 132:2169
16. Trentham D et al. Hyperimmune egg in the collagen-induced arthritis model and anti-inflammatory assays. Int Soc Rheumatol Ther (ISRT) 1998 [Abstract] p.23
17. Greenblatt HC Adalsteinssön O Kagen L. Administration to Arthritis Patients of a Dietary Supplement Containing Immune Egg: An Open-Label Pilot Study J Medicinal Food 1998 1:171-179
18. Karge, WH et al. A pilot study on the effect of hyperimmune egg protein on elevated cholesterol levels and cardiovascular risk factors J Medicinal Food 1999 2:51 63
19. Jacoby HI Moore G Wnorowski G. Inhibition of diarrhea by immune egg: a castor oil mouse model J Nutraceut Function Med Foods 2001 3:47
20. US Pat # 5,772,999 Method of preventing, countering or reducing NSAID-induced gastrointestinal damage by administering milk or egg products from hyperimmunized animals
21. Kizito FB. Improvements in quality of life for HIV/AIDS patients using hyperimmune egg 3rd Int AIDS Soc Conf HIV Pathogenesis and Treatment 2005 Abst #. MoPe11.2C43
22. Scheett TP et al. Increased muscular strength and enhanced muscle repair with hyperimmune egg protein supplementation National Strength & Conditioning Association Conference Supplement 2007 p.768
23. Scheett TP et al. Hyperimmune egg protein decreases submaximal heart rate and increases peak power J Am College Sports Med 2007 39:S36522
24. Scheett TP et al. Increased Muscular Strength and Enhanced Muscle Repair with Hyperimmune Egg Protein Supplementation. National Strength and Conditioning Association, Atlanta, GA, July, 2007
25. Scheett TP et al. Hyperimmune egg protein decreases submaximal heart rate and increases peak power J Am College Sports Med 2007 39:S36522
26. Netea MG et al. Increased voluntary exercise in mice deficient for tumour necrosis factor-alpha and lymphotoxin-alpha Eur J Clin Invest 2007 37:737
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Patent Links for Immune26
US Patents relating to the product:
6,803,035 Anti-diarrheal and method for using the same
6,729,265 Supplemented antibody feed to enter the circulating system of newborns
6,706,267 Glucosamine and egg for reducing inflammation
6,086,878 Method of increasing muscle protein and reducing fat in animals
5,772,999 Method of preventing, countering, or reducing NSAID-induced gastrointestinal damage
by administering milk or egg products from hyperimmunized animals
6,420,337 - CAF - Highly purified cytokine activating factor and methods of use - in water soluble fraction of the egg yolk
7,083,809 - CIF - Purified cytokine inhibitory factor - in lipid fraction of the egg yolk
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This comment on i26 is from webmd.com (link)
"I've used hyperimmune egg, I26, since 2001 for Crohn's disease. I take 2 servings a day. I've been in 'remission' beginning in the 3rd month after starting on it. My doctor was able to reverse my colostomy 5 months after starting using i26. I have almost no abdominal pain anymore, or diahrrea, and sleep through the night. I was at 112 lbs when starting on it, and I'm 5'10". Have been at 165-170 since 2003."
See also this WebMD page.